T-Lymphocyte Differentiation and Proliferation in the Absence of the Cytoplasmic Tail

Mutation of the -yc chain common to interleukin-2 (IL-2). IL4, IL-7, IL-9, and IL-15 receptors has been shown to be responsible for the X chromosome-linked severe combined immune deficiency (SCIOXI). Human SClDXl patients are characterized by an absence of T and natural killer cell differentiation. We report the case of a SClDXl patient who first had few detectable peripheral T cells, then developed, after haploidentical T-depleted bone marrow transplantation (BMT), up to 2,0001pL autologous T cells. These T cells have persisted over 8 years after BMT and were able to proliferate in the presence of mitogens and of some antigens, although